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ABSTRACT Background: Critical illness is a major ongoing health care burden worldwide and is associated with high mortality rates. Sodium-glucose cotransporter-2 inhibitors have consistently shown benefits in cardiovascular and renal outcomes. The effects of sodium-glucose cotransporter-2 inhibitors in acute illness have not been properly investigated. Methods: DEFENDER is an investigator-initiated, multicenter, randomized, open-label trial designed to evaluate the efficacy and safety of dapagliflozin in 500 adult participants with acute organ dysfunction who are hospitalized in the intensive care unit. Eligible participants will be randomized 1:1 to receive dapagliflozin 10mg plus standard of care for up to 14 days or standard of care alone. The primary outcome is a hierarchical composite of hospital mortality, initiation of kidney replacement therapy, and intensive care unit length of stay, up to 28 days. Safety will be strictly monitored throughout the study. Conclusion: DEFENDER is the first study designed to investigate the use of a sodium-glucose cotransporter-2 inhibitor in general intensive care unit patients with acute organ dysfunction. It will provide relevant information on the use of drugs of this promising class in critically ill patients. ClinicalTrials.gov registry: NCT05558098

RESUMO Antecedentes: A doença crítica é um importante ônus permanente da assistência médica em todo o mundo e está associada a altas taxas de mortalidade. Os inibidores do cotransportador de sódio-glicose do tipo 2 têm demonstrado consistentemente benefícios nos desfechos cardiovasculares e renais. Os efeitos dos inibidores do cotransportador de sódio-glicose do tipo 2 em doenças agudas ainda não foram devidamente investigados. Métodos: O DEFENDER é um estudo de iniciativa do investigador, multicêntrico, randomizado, aberto, desenhado para avaliar a eficácia e a segurança da dapagliflozina em 500 participantes adultos com disfunção orgânica aguda hospitalizados na unidade de terapia intensiva. Os participantes aptos serão randomizados 1:1 para receber 10mg de dapagliflozina e o tratamento padrão por até 14 dias ou apenas o tratamento padrão. O desfecho primário é um composto hierárquico de mortalidade hospitalar, início de terapia renal substitutiva e tempo de internação na unidade de terapia intensiva, até 28 dias. O monitoramento da segurança será rigoroso durante todo o estudo. Conclusão: O DEFENDER é o primeiro estudo desenvolvido para investigar o uso de um inibidor do cotransportador de sódio-glicose do tipo 2 em pacientes de unidade de terapia intensiva geral com disfunção orgânica aguda. O estudo fornecerá informações relevantes sobre o uso de medicamentos dessa classe promissora em pacientes críticos. Registro ClincalTrials.gov: NCT05558098

https://doi.org/10.5935/2965-2774.20230129-en

Guidelines from the Brazilian society of surgical oncology regarding indications and technical aspects of neck dissection in papillary, follicular, and medullary thyroid cancers
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Farias, Terence

; Kowalski, Luiz Paulo

; Dias, Fernando

; Barreira, Carlos S. Ritta

; Vartanian, José Guilherme

; Tavares, Marcos Roberto

; Vaisman, Fernanda

; Momesso, Denise

; Oliveira, Alexandre Ferreira

; Pinheiro, Rodrigo Nascimento

; Ribeiro, Heber Salvador de Castro

Archives of Endocrinology and Metabolism

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2023, Volume 67 Nº 4 elocation e000607

Resumo: En | Texto: En | PDF: En

ABSTRACT Objective: The purpose of these guidelines is to provide specific recommendations for the surgical treatment of neck metastases in patients with papillary, follicular, and medullary thyroid carcinomas. Materials and methods: Recommendations were developed based on research of scientific articles (preferentially meta-analyses) and guidelines issued by international medical specialty societies. The American College of Physicians’ Guideline Grading System was used to determine the levels of evidence and grades of recommendations. The following questions were answered: A) Is elective neck dissection indicated in the treatment of papillary, follicular, and medullary thyroid carcinoma? B) When should central, lateral, and modified radical neck dissection be performed? C) Could molecular tests guide the extent of the neck dissection? Results/conclusion: Recommendation 1: Elective central neck dissection is not indicated in patients with cN0 well-differentiated thyroid carcinoma or in those with noninvasive T1 and T2 tumors but may be considered in T3-T4 tumors or in the presence of metastases in the lateral neck compartments. Recommendation 2: Elective central neck dissection is recommended in medullary thyroid carcinoma. Recommendation 3: Selective neck dissection of levels II–V should be indicated to treat neck metastases in papillary thyroid cancer, an approach that decreases the risk of recurrence and mortality. Recommendation 4: Compartmental neck dissection is indicated in the treatment of lymph node recurrence after elective or therapeutic neck dissection; “berry node picking” is not recommended. Recommendation 5: There are currently no recommendations regarding the use of molecular tests in guiding the extent of neck dissection in thyroid cancer.

https://doi.org/10.20945/2359-3997000000607

Validation of Chronocancer camilosantanai† Santana, Tavares, Martins, Melo & Pinheiro (Crustacea, Decapoda, Brachyura) from the Romualdo Formation, Araripe Sedimentary Basin, Brazil
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Santana, William

; Tavares, Marcos

; Martins, Carlos Antônio Muniz

; Melo, José Patrício Pereira

; Pinheiro, Allysson P.

Papéis Avulsos de Zoologia

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2023, Volume 63 elocation e202363014

Resumo: En | Texto: En | PDF: En

Abstract Santana et al. (2022) described a new genus and species of fossil crab, Chronocancer camilosantanai, from carbonate concretions of the Romualdo Formation of the Araripe Sedimentary Basin. The journal in which the description appeared was published online only and the new name did not include a ZooBank registration number (LSID), as required for validation of new names in electronic-only publications. The present note serves to validate the name Chronocancer camilosantanai by fulfilling the ICZN conditions for nomenclatural availability. The date and authorship of the specific name, accordingly, are those of this note, not Santana et al. (2022).

https://doi.org/10.11606/1807-0205/2023.63.014

Six new records of decapod crustacean species (Anomura, Brachyura) from southern Brazil
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Lima, Daniel

; Boos, Harry

; Tavares, Marcos

Nauplius

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2023, Volume 31 elocation e2023015

Resumo: En | Texto: En | PDF: En

Abstract Five anomuran and one brachyuran species collected from continental shelf and slope off southern Brazil have their geographic ranges considerably extended southward: Neolithodes agassizii (Smith), Paguristes spectabilis McLaughlin and Provenzano, Pagurus heblingi Nucci and Melo, Phimochirus occlusus (Henderson), Mixtopagurus paradoxus A. Milne-Edwards, and the brachyuran Euchirograpsus antillensis Türkay. Pagurus heblingi was previously known only from its type locality (off Cabo Frio, Rio de Janeiro) and from off Espírito Santo. Paguristes spectabilis was known only from the holotype (off Trinidad, Caribbean Sea) and two additional females from off Rio de Janeiro. One female was found of the brachyuran Robertsella meridionalis Tavares and Gouvêa, a species previously known only from two males. Additionally, the occurrence of the hermit crabs Dardanus venosus (H. Milne Edwards) and Oncopagurus gracilis (Henderson), and the brachyuran Hexapanopeus paulensis Rathbun are confirmed for Santa Catarina. The record of the brachyuran Neopilumnoplax americana (Rathbun) from Santa Catarina (27°S) probably actually refers to Neopilumnoplax lipkeholthuisi Tavares and Melo, a species described from Rio Grande do Sul (33°S) and Mar del Plata (37°S).

https://doi.org/10.1590/2358-2936e2023015

An annotated catalogue of Echinodermata types in the Museu de Zoologia, Universidade de São Paulo, Brazil
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Martins, Luciana

; Marques, Alexandre Oliveira

; Fukuda, Marcelo Veronesi

; Tavares, Marcos

Papéis Avulsos de Zoologia

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2022, Volume 62 elocation e202262015

Resumo: En | Texto: En | PDF: En

Abstract The types of nominal species of Echinodermata in the collection of the Museu de Zoologia, Universidade de São Paulo are catalogued: Holothuroidea (19 species - 16 holotypes, 1 paratype and 2 neotypes) and Ophiuroidea (4 species - 1 neotype and 3 paratypes). Photographs of all the type specimens are given. A brief account of the history of the MZUSP’s echinoderm collections is presented.

https://doi.org/10.11606/1807-0205/2022.62.015

OPERATIONAL PERFORMANCE OF AN AGRICULTURAL TRACTOR AS A FUNCTION OF MIXTURE PROPORTIONS AND TYPE OF BIODIESEL
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Tavares, Marcos S.

; Camara, Felipe T. da

; Lopes, Afonso

; Pinto, Antonio A.

Engenharia Agrícola

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2022, Volume 42 Nº spe elocation e20220072

Resumo: En | Texto: En | PDF: En

ABSTRACT The growing demand for clean energy aimed at reducing greenhouse gas emissions associated with the oil crises has encouraged the search for biofuels, among which biodiesel has stood out in the gradual replacement of diesel. This study aimed to evaluate the performance of an agricultural tractor fueled with four types of biodiesels (peanut, sunflower, soybean, and waste frying oil) added to diesel at five proportions (0, 25, 50, 75, and 100% biodiesel, that is, B0, B25, B50, B75, and B100, respectively). The experiment was carried out at the Laboratory of Biofuel and Machinery Testing at FCAV–UNESP. A Valtra BM100 4×2 FWD tractor with a power of 74 kW (100 hp) was used. The drawbar pull force (DF), displacement velocity (V), drawbar power (DP), volumetric fuel consumption (VC), weight fuel consumption (WC), and specific fuel consumption (SC) were studied. The factors did not influence DF, V, and DP. The proportion factor influenced (p<0.01) the volumetric fuel consumption, in which diesel S50 was 14% more efficient than B100. Weight fuel consumption was influenced by the type of biodiesel in the blend. Diesel had the lowest specific fuel consumption (328 g kW h−1). The biodiesel fraction showed a direct relationship with the consumption parameters, with sunflower showing the lowest WC value in the B75 and B100 blends.

https://doi.org/10.1590/1809-4430-eng.agric.v42nepe20220072/2022

Tuleariocaris neglecta Chace, 1969 (Crustacea: Caridea: Palaemonidae) associated with the sea urchin Astropyga magnifica Clark, 1934 (Echinoidea: Diadematidae) in the Alcatraz Archipelago, southeastern Brazil
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Tavares, Marcos

; Mendonça Júnior, Joel Braga de

Papéis Avulsos de Zoologia

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2022, Volume 62 elocation e202262038

Resumo: En | Texto: En | PDF: En

Abstract The caridean shrimp Tuleariocaris neglecta Chace, 1969, is reported from the Alcatraz Archipelago (24°S, off the coast of southeastern Brazil) in association with the sea urchin Astropyga magnifica Clark, 1934. This finding significantly increases the known range of this species from 20°S to 24°S. An overview of the species in Tuleariocaris with their respective associated host sea urchins is provided.

https://doi.org/10.11606/1807-0205/2022.62.038

Response to the letter: Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): Pioneers's Point of View
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Tincani, Alfio

; Lehn, Carlos

; Cernea, Cláudio

; Queiroz, Emilson

; Dias, Fernando

; Walder, Fernando

; Hojaij, Flávio

; Monteiro, Francisco

; Kligerman, Jacob

; Podesta, José

; Brandão, Lenine

; Mello, Luiz Eduardo Barbalho de

; Medina, Luiz

; Abrahao, Márcio

; Tavares, Marcos

; Barbosa, Mauro

; Cervantes, Onivaldo

; Demétrio, Paula

; Curioso, Ricardo

; Lima, Roberto

; Arap, Sérgio

; Vasconcellos, Sylvio

Archives of Endocrinology and Metabolism

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Dez 2021, Volume 65 Nº 6 Páginas 860 - 861

Resumo: En | Texto: En | PDF: En

https://doi.org/10.20945/2359-3997000000425 1 downloads

Transoral thyroidectomy: A reflexive opinion on the technique
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Tincani, Alfio

; Lehn, Carlos

; Cernea, Cláudio

; Queiroz, Emilson

; Dias, Fernando

; Walder, Fernando

; Hojaij, Flávio

; Monteiro, Francisco

; Kligerman, Jacob

; Podesta, José

; Brandão, Lenine

; Mello, Luiz Eduardo Barbalho de

; Medina, Luiz

; Abrahao, Márcio

; Tavares, Marcos

; Barbosa, Mauro

; Cervantes, Onivaldo

; Demétrio, Paula

; Curioso, Ricardo

; Lima, Roberto

; Arap, Sérgio

; Vasconcellos, Sylvio

Archives of Endocrinology and Metabolism

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Jun 2021, Volume 65 Nº 3 Páginas 396 - 399

Resumo: En | Texto: En | PDF: En

https://doi.org/10.20945/2359-3997000000383 128 downloads

10.

First record and a new species of Euphrosynoplax (Crustacea: Pseudorhombilidae) from the southwestern Atlantic
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Tavares, Marcos

; Santana, William

Papéis Avulsos de Zoologia

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2021, Volume 61 elocation e20216166

Resumo: En | Texto: En | PDF: En

Abstract A new species of deep-water brachyuran crab, Euphrosynoplax dincao, from southeastern Brazil is described and illustrated. The genus Euphrosynoplax currently consists of two species, E. clausaGuinot, 1969, and E. campechiensisVázquez-Bader & Gracia, 1991, both only known from the Gulf of Mexico. The new species can be easily separated from its northern counterparts by a suite of carapace and appendage characters. Euphrosynoplax campechiensis is recorded for the first time from the Caribbenan Sea (Guadeloupe and between Saint Kitts and Nevis).

https://doi.org/10.11606/1807-0205/2021.61.66 58 downloads

11.

SEM studies on first and second gonopod morphology in Mithracidae (Decapoda: Brachyura)
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Lianos, Laira

; Mollemberg, Michelle

; Zara, Fernando José

; Tavares, Marcos

; Santana, William

Nauplius

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2021, Volume 29 elocation e2021039

Resumo: En | Texto: En | PDF: En

Abstract Gonopods are phylogenetically important morphological characters, and in several cases providing diagnostic characters to support taxonomic and phylogenetic studies. Relatively few studies, however, have emphasized in-depth descriptions of gonopods, and the functional morphology of these structures are poorly understood. We use SEM to describe and illustrate the two pairs of gonopods (G1 and G2) of nine species of Mithracidae (Majoidea) and of Macrocoeloma trispinosum Latreille, 1825, recently relocated to Epialtidae (Majoidea). The G1 was found to present the typical characteristics of Majoidea: long, with a mesial suture, setae inserted from the base to the distal second third and sensilla in the apical plate; the G2 is always short and conical. The apical region of the G1 was diagnostic for the species analyzed, which could provide important characters for differentiating among the majoids; and also for studying the functional, reproductive, and phylogenetic significance of these structures.

https://doi.org/10.1590/2358-2936e2021039 32 downloads

12.

A new species of Gammarus Fabricius, 1775 (Crustacea: Amphipoda: Gammaridae) from extreme high-altitude Lake Tong Tso, Qinghai-Tibetan Plateau
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Andrade, Luiz Felipe

; Tavares, Marcos

; Senna, André Resende de

Papéis Avulsos de Zoologia

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2021, Volume 61 elocation e20216146

Resumo: En | Texto: En | PDF: En

Abstract A new species of the genus Gammarus Fabricius, 1775 is described from Lake Tong Tso, an extreme high-altitude lake in the Qinghai-Tibetan Plateau. Gammarus pontual sp. nov. is considered part of the Gammarus lacustris G.O. Sars, 1863 group, which is characterized by having the inner ramus of uropod 3 longer than half the length of the outer ramus, and by having both rami covered with plumose setae. The new species stands apart from their congeners, mainly, by the following combination of characters: head with cephalic lateral lobe truncated; gnathopods 1-2 propodus weakly armed, with 1 stout seta defining palm; palm longer than posterior margin of propodus, with 1 main stout seta medially; pereopods 5-7 basis slender, posterior margin crenulate; epimeral plate 1 posterior margin produced into a short spine, facial ridge present; epimeral plates 2-3 posteroventral corner sharply pointed; uropod 3 rami covered with plumose setae, inner ramus about 80% the length of the outer ramus; telson apex with 2 stout setae on each side.

https://doi.org/10.11606/1807-0205/2021.61.46 144 downloads

13.

“Green July” 2020 and Another Good Reason to Quit Smoking: Help to Stop Spreading SARS-COV-2 and Save Lives!
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Brescia, Marilia D'Elboux Guimarães

; Montenegro, Fabio Luiz de Menezes

; Arap, Sergio Samir

; Kulcsar, Marco Aurelio Valmondes

; Tavares, Marcos Roberto

; Kowalski, Luiz Paulo

International Archives of Otorhinolaryngology

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Dez 2020, Volume 24 Nº 4 Páginas 395 - 396

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0040-1716571 254 downloads

14.

High Risk of COVID-19 Infection for Head and Neck Surgeons
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Kulcsar, Marco Aurélio

; Montenegro, Fabio L.

; Arap, Sergio S.

; Tavares, Marcos Roberto

; Kowalski, Luiz Paulo

International Archives of Otorhinolaryngology

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Jun 2020, Volume 24 Nº 2 Páginas 129 - 130

Resumo: En | Texto: En | PDF: En

https://doi.org/10.1055/s-0040-1709725 690 downloads

15.

Yet another record of Scylla serrata Forsskål, 1775 (Crustacea: Decapoda: Portunidae) from the western Atlantic
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Metri, Cassiana Baptista

; Guilherme, Pablo Damian Borges

; Tavares, Marcos

Papéis Avulsos de Zoologia

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2020, Volume 60 elocation e20206062

Resumo: En | Texto: En | PDF: En

Abstract The Indo-Pacific edible swimming crab Scylla serrata is reported here for the fifth time from the western Atlantic including a failed attempt of introduction to Florida for aquaculture purposes in the years 1960’s. The species had been recorded from Brazil in the early 1980’s and in 2011 and from the Caribbean coast of Colombia in 2013. The capture of a third specimen in southeastern Brazil on 24 August 2020 is discussed here. On all occasions individuals found in Brazil were adults captured alive near port areas. The occurrence of S. serrata in disparate time periods in the western Atlantic (1983, 2011, 2013 and 2020) is regarded as an indication of low inoculation pressure.

https://doi.org/10.11606/1807-0205/2020.60.62 113 downloads

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